Resveratrol
Resveratrol drives the liver to clear its damaged parts, damps the swelling switch, lifts adiponectin and AMPK energy, frees nitric oxide, trims lipids.
What the evidence shows
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Twenty people with bowel disease took resveratrol before surgery, and the surgeon's own tissue told the story: proliferation of the abnormal cells was 5% lower in the removed tissue.
In a yearlong placebo-controlled trial in older adults with memory decline, resveratrol lowered MMP9, an inflammatory enzyme, in the fluid around the brain.
In a randomized, triple-blind, placebo-controlled trial in women, resveratrol raised the mitochondrial DNA copy number of granulosa cells against placebo.
Pooled across 23 trials and 1005 participants, it took 1.93 centimeters off the waist, and the waist is where abdominal fat is read.
Resveratrol clamps the master growth switch directly and wakes the two energy sensors that order a cell to clear out its own wreckage, clumped Parkinson's and Alzheimer's proteins included.
In a two-month randomized trial, muscle biopsies showed resveratrol switched on AMPK and its fat-burning signal.
What resveratrol does in volunteers is shift the readings a fasting body shifts: blood sugar and blood-fat markers move, and the lining of the vessels works better with them.
Cut radiation's chromosome damage in mouse marrow, a day and a month after exposure, given before or after.
Wakes sirtuin, lifts adiponectin, restores nitric oxide to the vessel lining and trims blood fats.
Grape skin's signature compound wakes the fuel sensor, lets tissue answer insulin more readily and tells the liver to hold its sugar back.
Seven databases, 27 studies, three polyphenols judged head-to-head under one set of criteria — resveratrol placed second, behind curcumin.
The compound that opened this field: it wakes sirtuins, the fuel sensor and the antioxidant switch through a plant's own stress signal.
Rouses sirtuin in kidney cells, helping each filtering unit hold protein and pass only waste.
In myosin-immunized animals it preserved cardiac function, held back the heart-weight increase, and reduced cellular infiltration, fibrosis and inflammatory cytokines together — the inflammation and the scarring it leaves, in one result.
Red wine's famous polyphenol curbs the enzyme that burns NAD+ during DNA repair, so less of that precious coenzyme is spent in wasted fire.
Knotweed root, Hu Zhang in Chinese herbals, is a rich source of resveratrol, which wakes the nitric oxide enzyme of the endothelium so arteries ease open.
The lining of the blood vessels is where animal studies show it most clearly.
The polyphenol that improves fasting insulin and glucose in a dose-response meta-analysis of controlled trials, defending metabolic health against obesogen-driven disruption.
Resveratrol improved flow-mediated dilation by 1.43%, with ICAM-1 down 7.09; four of six trials moved the measure.
Resveratrol lowered plaque more than placebo in people with gum disease, and in rats it halved the loss of jawbone.
Silences senescent cells rather than killing them, blocking their inflammatory broadcast.
In a randomized trial, muscle biopsies showed resveratrol raised the activated form of AMPK, the cell's energy sensor.
In human hair follicles kept alive outside the body, resveratrol lengthened the growing shafts and held more follicles in their growth phase.
Across 15 randomized trials in 896 people with type 2 diabetes, resveratrol lowered insulin resistance against control.
Rat erectile model: the cavernosal smooth-muscle-to-collagen ratio rose toward control values, the structural measure that determines whether expanding tissue can seal the outflow veins.
A pooled analysis of human trials reports a reduction in triglyceride.
Pooled across 17 studies, resveratrol improved the widening of arteries with blood flow, the vessel lining's own nitric-oxide signal.
Where it appears
28 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ACB (Cell-Cycle Checkpoint Restraint)
- ALZ (Memory Preservation)
- Anti-Fatigue (Cellular Energy Endurance)
- Appetite Suppressant (Hunger Signal Control)
- Autophagy Activator (Cellular Self-Renewal)
- Ceramide Blocker (Lipotoxicity Neutralizer)
- EKG Cardioprotective (Contractile Reserve)
- Event Horizon (Post-Ethanol Restoration)
- Force Field (Genomic Radioprotection)
- GLP-1 Activator (Endogenous Incretin Support)
- Glucose Blocker (Postprandial Control)
- Holy Grail (Fat Leaves As Breath)
- Hormesis (Adaptive Stress Conditioning)
- Jing Force (Kidney Restoration)
- Myocarditis Antidote (Cardiac Inflammation Resolution)
- NAD+ Booster (Cellular Energy Currency)
- Niagra (Desire, Arousal & Climax)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Obesogen Blocker (Endocrine Disruptor Defense)
- Pulsar (Vascular Pressure Regulation)
- Sabretooth (Periodontal Defense)
- Senolytic (Senescent Zombie Cell Clearance)
- SIRT1 Activator (Caloric-Restriction Mimetic)
- Super Tonic Hair (Follicular Restoration)
- Thermo (Thermogenic Disposal)
- Thunder (Erectile Performance)
- Triglyceride Decimator (Serum Lipid Reduction)
- Victorious (Antiviral Immunity)