Quercetin
Sophora japonica
Quercetin lowered systolic pressure 3.04 mmHg in the Journal of the American Heart Association pooled analysis; an independent 2024 analysis of 20 randomized trials found it reduced systolic pressure too.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
In human cells and in mice, quercetin cuts off the blood supply a growth must recruit, and starves abnormal liver cells of sugar besides.
Quercetin kept AMPK switched on in the visceral fat of mice on a high-fat diet, in two independent laboratories; a third laboratory saw no change in the fat under the skin.
In animals it reduces fatty-liver severity.
Lowered liver fat and liver enzymes in 41 people with fatty liver, each their own control in a crossover trial.
The flavonoid antihypertensive — human randomized trials show blood-pressure reduction, a vasoprotective polyphenol of broad reach.
The flavonol of onions and capers: it helps insulin do its work at the cell and turns down the enzymes by which the liver makes new glucose.
Lowered liver fat and liver enzymes in 41 people with fatty liver, each serving as their own control in a crossover trial.
Across 7 trials and 587 people, lowered blood pressure 3.04/2.63 mm Hg; a second pooling cut CRP.
The onion-skin flavonol quercetin guards renal cells from untimely death and restrains TGF-beta, the growth factor that lays down scar in the kidney.
In human mast cells grown in the lab, quercetin cut allergy-triggered histamine release by 82%.
Fewer animals developed the disease at all.
The onion's quercetin blocks two drains on NAD+ at once — the enzyme that consumes it and the repair enzyme that spends it — so more remains for cell repair.
Across seven randomized trials, lowered systolic pressure about 3 mm Hg and diastolic 2.6.
Lowered fasting insulin and glucose across 20 metabolic-syndrome trials, and CRP inflammation across seven.
Taken by mouth, quercetin cut the loss of jawbone around the teeth in two independent laboratories.
In the first human senolytic trial, dasatinib plus quercetin reduced senescent-cell burden in fat tissue.
Quercetin shifts SIRT1 in animals and in cells alike, and reference databases list it among the direct activators.
Where it appears
24 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ACB (Cell-Cycle Checkpoint Restraint)
- Adipocyte Apoptosis (Mature Fat Cell Clearance)
- Autophagy Activator (Cellular Self-Renewal)
- Ceramide Blocker (Lipotoxicity Neutralizer)
- EKG Cardioprotective (Contractile Reserve)
- Endurance Eternal (Pigment Preservation)
- Gainz (Muscle, Strength & Recovery)
- Glucose Blocker (Postprandial Control)
- Holy Grail (Fat Leaves As Breath)
- Hormesis (Adaptive Stress Conditioning)
- Jing Force (Kidney Restoration)
- Liver Regenerator (Hepatic Restoration)
- Lung Power (Respiratory Capacity)
- Myocarditis Antidote (Cardiac Inflammation Resolution)
- NAD+ Booster (Cellular Energy Currency)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Obesogen Blocker (Endocrine Disruptor Defense)
- Peel (Flavonoid Powerhouse)
- Pulsar (Vascular Pressure Regulation)
- Sabretooth (Periodontal Defense)
- Senolytic (Senescent Zombie Cell Clearance)
- SIRT1 Activator (Caloric-Restriction Mimetic)
- Super Tonic Hair (Follicular Restoration)
- Victorious (Antiviral Immunity)