Ashwagandha
Withania somnifera
Withaferin A kills abnormal breast cells in the dish by flooding them with reactive oxygen while leaving a normal human breast line untouched — the toxicity is selective.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
In a 90-day randomized, double-blind, placebo-controlled trial of 130 healthy adults under stress, ashwagandha root improved recall on the Cambridge memory tests and cut errors in recalling patterns.
Lowers cortisol, raises thyroid hormone in subclinical hypothyroidism, and raises testosterone while cutting body fat.
In a hundred adults over twenty-four weeks, double-blind, ashwagandha took off 8.46 kg against 2.41 on placebo, with stress scores improving alongside.
Ashwagandha's withanolides switch on the body's antioxidant defenses by acting on their master regulator; delete that regulator and the effect is abolished, which proves cause.
Winter cherry of Indian medicine, here for calm without sedation: it lifts GABA tone and plasticity, lowers cortisol, and deepens the night's sleep.
Withania somnifera keeps irradiated rat heart muscle whole.
The withanolide-rich leaf raised both lipases and the browning machinery, cutting stored fat inside the cell to 41.58%.
The adaptogenic keystone — withanolides lower the cortisol that suppresses the reproductive axis while human randomized trials report gains in sperm count, motility and testosterone.
Randomized placebo-controlled trials in women raised desire and arousal on the Female Sexual Function Index, and a separate pooled analysis lowered serum cortisol.
Withaferin A, the root's withanolide, protected mice from paracetamol destroying the liver; mice bred without NRF2 got none of it.
The withanolide-rich leaf raised both lipase genes and the browning genes, cutting stored fat inside the cell to 41.58%.
Ashwagandha significantly reduced serum cortisol and perceived-stress scores in randomized placebo-controlled trials (meta-analyses: ~11-33% cortisol reduction across 12 randomized trials and 1000+ participants).
Withanolides lower stress cortisol and quiet the inflammation that pushes follicles to rest early.
In 100 adults over 24 weeks, 8.46 kg lost against 2.41 on placebo, with stress scores improving.
The Ayurvedic root for strength: it lowers cortisol's hold, raises testosterone and restores mood and desire, the calm that lets vigor return.
Across 9 randomized trials and 558 people, lowered perceived stress, anxiety scores and cortisol against placebo.
Where it appears
23 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ACB (Cell-Cycle Checkpoint Restraint)
- ALZ (Memory Preservation)
- Anti-Fatigue (Cellular Energy Endurance)
- Appetite Suppressant (Hunger Signal Control)
- Autonomous (Executive Command)
- Ecstatic (Nervous System Stand-Down)
- Endurance Eternal (Pigment Preservation)
- Event Horizon (Post-Ethanol Restoration)
- Force Field (Genomic Radioprotection)
- Gainz (Muscle, Strength & Recovery)
- Hormesis (Adaptive Stress Conditioning)
- Spice (Anti-Inflammatory Polyphenol Powerhouse)
- Lipolytic (Stored-Fat Mobilization)
- Male Fertility (Seminal Quality)
- Niagra (Desire, Arousal & Climax)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Obesogen Blocker (Endocrine Disruptor Defense)
- Purge (Intestinal Clearance)
- Rewire (Total Brain Reset)
- Super Tonic Hair (Follicular Restoration)
- Thermo (Thermogenic Disposal)
- Thunder (Erectile Performance)
- Trinity (Mind Body Spirit Harmonizer)