Alpha-lipoic acid
Alpha-lipoic acid restored AMPK activation in the fat under the skin of rats after the loss of ovarian hormones.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
Alpha-lipoic acid binds heavy metals, regenerates glutathione and, across a meta-analysis of controlled trials, lowered fasting glucose and body weight.
Across a dose-response meta-analysis of controlled trials, alpha-lipoic acid lowered body weight and BMI.
Alpha-lipoic acid recharges the mitochondria: it cofactors the enzymes that turn fuel into energy and recycles vitamins C and E once spent.
Given to rats after twenty-eight days of lead rather than alongside it, alpha-lipoic acid still lowered the metal in their blood: a test of removal, not prevention.
A sulfur-bearing antioxidant the body makes itself: lipoic acid improves insulin's reach, lowers fasting insulin, trims blood lipids and body fat.
Wakes the cell's fuel-sensing switch and frees the master antioxidant controller; cells build more mitochondria.
Blunts the sugar-branding of kidney proteins and helps the filter keep its protein inside.
The mitochondrial thiol antioxidant — it regenerates the seminal antioxidant pool and feeds the Krebs cycle sperm motility depends on.
Alpha-lipoic acid left less jawbone damage and more collagen around the teeth in rats.
Α-Lipoic acid prevented senescence, cell-cycle arrest and inflammatory signaling in fibroblasts by reducing oxidative stress and SA-β-gal — shown in laboratory study.
Alpha-lipoic acid reduced BMI and body weight across a dose-response analysis, and the response held in a straight line.
Where it appears
17 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- Adipocyte Apoptosis (Mature Fat Cell Clearance)
- Ascendance (Analgesic & Anti-Inflammatory)
- Ceramide Blocker (Lipotoxicity Neutralizer)
- Event Horizon (Post-Ethanol Restoration)
- Female Fertility (Oocyte Competence)
- Force Field (Genomic Radioprotection)
- Heavy Metal Detox (Toxic Burden Excretion)
- Holy Grail (Fat Leaves As Breath)
- Hormesis (Adaptive Stress Conditioning)
- Jing Force (Kidney Restoration)
- Male Fertility (Seminal Quality)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Obesogen Blocker (Endocrine Disruptor Defense)
- Sabretooth (Periodontal Defense)
- Senolytic (Senescent Zombie Cell Clearance)
- SIRT1 Activator (Caloric-Restriction Mimetic)
- Thermo (Thermogenic Disposal)