Body temperature control
Hypothalamic set-point regulation
Also searched as Hypothalamic set-point regulation.
Cold intolerance and heat intolerance are different failures. One is usually metabolic rate or peripheral circulation; the other is usually set-point or sweat response.
In depth
Core temperature maintenance across metabolic rate, circulation and the hypothalamic set-point.
What drives it
Thyroid increases it.
10.1038/s41598-020-66697-0 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1038/s41598-020-66697-0
Mitochondrial energy increases it.
10.1146/annurev-physiol-021119-034405 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1146/annurev-physiol-021119-034405
Builds mitochondria increases it.
10.1371/journal.pbio.0030101 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1371/journal.pbio.0030101
Blood flow (nitric oxide) increases it.
25260636 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Sources: doi 10.1016/j.molmet.2023.101755; PMC9967593. doi 10.1016/j.molmet.2023.101755 · PMC9967593
Sympathetic drive reduces it.
NBK499843 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so.
Lowers cortisol reduces it.
10.3390/biom11111573 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “Prolonged exposure to glucocorticoid suppresses the function of human BAT”. doi 10.3390/biom11111573
Supports weight management reduces it.
NBK499843 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so.
Muscle increases it.
10.3389/fphys.2017.00889 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “As in other large mammals, skeletal muscles are the primary source of heat production recruited in cold-exposed humans”. doi 10.3389/fphys.2017.00889
Iron status increases it.
PMC6531837 — 8989508 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. PMC6531837
Iron & oxygen carriage increases it.
10.3390/jfmk10030362 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.3390/jfmk10030362
Hydration & electrolytes increases it.
10.1371/journal.pone.0220384 — 28202441 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1371/journal.pone.0220384
Estrogen balance increases it.
10.1210/en.2010-0573 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1210/en.2010-0573
Temperature stability in menopause reduces it.
PMC12051537 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. PMC12051537
Cellular aging reduces it.
10.1155/2018/8306154 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “Aging is associated with an attenuated physiological ability to dissipate heat”. doi 10.1155/2018/8306154 · PMC4312844
What it drives
It reduces Temperature stability in menopause.
https://www.amjmed.com/article/S0002-9343(05)00904-6/fulltext — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so.
It increases Physical performance.
10.1186/s40101-024-00377-0 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.1186/s40101-024-00377-0
It increases Sleep.
10.3389/fnins.2019.00336 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3389/fnins.2019.00336
It reduces Daily energy.
10.3390/life11111149 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3390/life11111149
It increases Mood.
Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. This link rests on the reviews of this outcome as a whole, and no effect size specific to it has been reported.
It increases Heart & blood pressure.
10.3389/fphys.2026.1856143 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3389/fphys.2026.1856143
It increases What The Cold Turns On.
Cold exposure is the stimulus; the response depends on how far core temperature actually moves. Carried by the hormesis, inflammaging and thermogenesis reviews. doi 10.1002/med.21743
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.