Clotting
Coagulation Cascade
Also searched as Coagulation Cascade.
You want it restrained: it is the arm that drives clots in slow-moving veins.
In depth
The coagulation cascade — the enzyme chain ending in thrombin and the fibrin net that sets a clot solid.
What drives it
Calms inflammation increases it.
The extrinsic-cascade switch. Verbatim: 'preventing ischemic-induced oxidative damage of brain endothelial cells and activation of tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1), and NF-kB' (PMID 30414726). Corroborated independently: puerarin 'attenuated ox-LDL induced tissue factor (TF) expression' while inhibiting NF-kB in human endothelial cells. NF-kB up raises TF; TF starts the cascade. drawn as one step because tissue factor is the mediator, not a second cause. PMID 30414726
Vitamin K status increases it.
PMC7395276 — NBK551578 — Verbatim (Japanese, Okayama University Graduate School of Pharmaceutical Sciences): vitamin K, abundant in natto, is 'conversely a substance necessary for the activation of blood coagulation factors'. Canonical biochemistry - it is the vitamin K cycle that warfarin targets. not a trial result, and no efficacy claim. Recorded because it is a formula-fighting risk: the reason the K2-free nattokinase sourcing spec is mandatory. PMC7395276
What it drives
It increases Clot formation.
The mesh that sets the clot. Verbatim: 'Fibrin clot formation is the ultimate common event in the coagulation cascade leading to thrombus formation' (PMC7867291). Cascade topology, not an intervention effect size. PMC7867291
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.