Genistein
Soy's isoflavone favors the beta estrogen receptor, the gentler partner in breast, bone and vessel, offering plant support where estrogen wanes.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
In human bladder cells and mice, blunted NF-κB, the survival switch abnormal cells use against treatment.
Soy's genistein raised programmed fat-cell death in the subcutaneous inguinal fat of mice. Apoptosis in the inguinal fat rose 290%.
Soy's isoflavone drives the cell's energy sensor both ways: cripple the sensor and genistein stops working, force it on and the effect accelerates.
Timing is the active ingredient.
Its chemical family is the best-mapped for reversing direction with quantity - protective in small amounts, the opposite in large - and that turn was charted in the laboratory.
The soy isoflavone genistein raises NAMPT, speeding the step where spent nicotinamide becomes NAD+ again.
Genistein raises one arm of the rat liver's power to clear carcinogens.
In human vessel-lining cells aged by oxidative stress, genistein held senescence back by quieting the TXNIP-NLRP3 inflammation axis.
Soy's genistein raises SIRT1 in animal metabolic and heart models.
Where it appears
10 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ACB (Cell-Cycle Checkpoint Restraint)
- Adipocyte Apoptosis (Mature Fat Cell Clearance)
- Autophagy Activator (Cellular Self-Renewal)
- Force Field (Genomic Radioprotection)
- Hormesis (Adaptive Stress Conditioning)
- NAD+ Booster (Cellular Energy Currency)
- Niagra (Desire, Arousal & Climax)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Senolytic (Senescent Zombie Cell Clearance)
- SIRT1 Activator (Caloric-Restriction Mimetic)