Fisetin
Fisetin, a dietary flavonol, blocks the cell's main growth switch on both arms and turns on the master clean-up and antioxidant regulators, switching autophagy on; the same regulator drives tau clearance. Cell studies.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
A four-arm factorial separated supplement from exercise, and the fisetin-only arm lost weight without the training.
Rodent hearts and kidneys show that response.
In strawberries sits fisetin: it reins in the repair enzyme that drains NAD+ while lifting the sirtuins that read that NAD+ and turn it into upkeep.
Aging cells that refuse to die linger and leak irritants into the tissue around them. Fisetin, from strawberry and persimmon, clears those spent cells away.
Reduced senescence markers and extended lifespan in aged mice; an early human study found fewer senescent blood cells.
Fisetin nudges SIRT1 directly and pushes it harder by the indirect road, raising both the amount of enzyme present and the marks it leaves on its targets in animal tissue.
Where it appears
9 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- Autophagy Activator (Cellular Self-Renewal)
- Endurance Eternal (Pigment Preservation)
- Holy Grail (Fat Leaves As Breath)
- Hormesis (Adaptive Stress Conditioning)
- NAD+ Booster (Cellular Energy Currency)
- Peel (Flavonoid Powerhouse)
- Senolytic (Senescent Zombie Cell Clearance)
- SIRT1 Activator (Caloric-Restriction Mimetic)
- Victorious (Antiviral Immunity)