Beta-3 receptor signaling
β3 receptor↑
Also searched as β3 receptor.
You want it answering. In human fat it drives lipolysis and thermogenesis, and in the bladder it relaxes smooth muscle — the action approved drugs such as mirabegron are built on. Its density in human subcutaneous fat is lower than in rodents, so read the model named in every receipt below: a result in a mouse or a cultured cell is exactly that.
In depth
The beta-3 adrenergic receptor, encoded by ADRB3 and present in human fat, bladder, heart, vessels and brain. Catecholamines bind it; it signals through cAMP to release stored fat and raise heat production.
What drives it
Alertness chemical increases it.
Among the 3 beta-adrenergic receptor subtypes, beta3-AR is the predominant receptor expressed in rodent brown adipocytes and is essential in regulating lipolysis and thermogenesis. Adrenergic activation of…. PMID 25565203
Growth signal relay increases it.
'phosphorylation of beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes' (pmc6001906, title). Carries the same species caveat as every b3ar edge: in human adipose the lipolytic beta receptors are beta-1 and beta-2.
Adrenaline responsiveness reduces it.
Reversing obesity-induced catecholamine resistance in mice restored signaling in response to a beta-3 adrenergic agonist. PMID 24368730
What it drives
It increases Daily energy burn.
A single 200 mg oral dose of the β3-adrenergic agonist mirabegron increased brown adipose tissue 18F-FDG uptake in all twelve healthy male subjects and raised resting metabolic rate by 203 ± 40 kcal/day (about 13%) versus placebo, with BAT activity predicting the rise in metabolic rate. doi 10.1016/j.cmet.2014.12.009 · PMID 25565203
It reduces Visceral fat.
Chronic treatment of lean and obese rats with the selective beta3-adrenergic agonist CL 316,243 reduced the weight of retroperitoneal (intra-abdominal) white adipose tissue and shrank white adipocytes relative to untreated controls. doi 10.2147/DDDT.S73891
It increases Heat instead of storage.
Mirabegron led to higher BAT metabolic activity as measured via 18F-fluorodeoxyglucose using positron emission tomography combined with computed tomography in all twelve healthy male subjects (p = 0.001),…. PMID 25565203
It increases Fat burning.
the beta3-AR plays a critical role in regulating lipolysis, glycolysis, and thermogenesis. ... reduction of beta3-AR lowered agonist-mediated increases in intracellular cAMP, lipolysis, and…. PMC8262278
It increases Fat-burning hormone.
Adiponectin, a WAT-derived [hormone], increased… chronic mirabegron therapy increased BAT metabolic activity. PMID 31961826
It increases Insulin sensitivity.
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity… higher insulin sensitivity (36% increase) and secretion, accompanied by a 34% increase in glucose effectiveness. PMID 31961826
It increases Lowers cholesterol.
there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. PMID 31961826
It increases Muscle glucose uptake.
activation of the beta3-AR with the selective beta3-AR agonist mirabegron increases human BAT metabolic activity, whole-body energy expenditure, as well as plasma FFA and BAT glucose uptake. PMID 31961826
It increases Body temperature control.
a beta3-AR agonist can stimulate human BAT thermogenesis… increased resting metabolic rate by 203 +/- 40 kcal/day (+13%; p = 0.001). PMID 31961826
It increases Blood pressure.
the elevations in HR, SBP, and myocardial oxygen consumption with this dosage of mirabegron may confer too great a cardiovascular risk for clinical treatment of metabolic dysfunction in obese patients. PMID 31961826
It increases Cardiac output.
the elevations in HR, SBP, and myocardial oxygen consumption… may confer too great a cardiovascular risk. PMID 31961826
It increases Urinary health.
mirabegron, a beta3-AR agonist indicated for the treatment of overactive bladder… beta3-AR agonists relax the detrusor muscle. PMID 31961826
It increases The cell's go-signal.
The betaAR stimulation elevates intracellular cAMP production through the guanine nucleotide-binding alpha stimulating protein (Gnas)... Elevated cAMP levels activate protein kinase A (PKA). PMID 1435297
It increases Releases stored fat.
PMC1909425 — A species caveat that must travel with this edge. Verbatim: 'Mouse adipocytes express three subtypes of beta-adrenergic receptors: beta1-AR, beta2-AR, and beta3-AR. In human adipose tissue, only BETA1 and BETA2 receptors induce lipolysis' (j Lipid Res, ATGL and the lipolytic catabolism of cellular fat stores). ⇒ beta-3 is the rodent lipolysis receptor. The edge is drawn because the beta-adrenergic route to lipolysis is not in doubt, but any claim resting on beta-3 specifically is a mouse claim until shown otherwise in people. PMC1909425
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.