Daily energy burn
Total energy expenditure (TEE)
Also searched as Total energy expenditure (TEE).
You want it higher. It is the whole-body output, not the mechanism: uncoupling is how heat is made, this is how much is spent. A trial that reports only weight has not measured it.
In depth
Total energy expenditure — the calories the body actually spends, measured by indirect calorimetry or doubly labeled water rather than inferred from weight change.
What drives it
Beta-3 receptor signaling increases it.
A single 200 mg oral dose of the β3-adrenergic agonist mirabegron increased brown adipose tissue 18F-FDG uptake in all twelve healthy male subjects and raised resting metabolic rate by 203 ± 40 kcal/day (about 13%) versus placebo, with BAT activity predicting the rise in metabolic rate. doi 10.1016/j.cmet.2014.12.009 · PMID 25565203
Heat instead of storage increases it.
Deleting the mitochondrial uncoupling protein UCP1 abolished diet-induced thermogenesis and caused obesity on the same food intake at thermoneutrality, showing that mitochondrial uncoupling is what raises energy expenditure. doi 10.1016/j.cmet.2008.12.014 · PMID 19187776
What it drives
It reduces Supports weight management.
In this eight-month randomised controlled trial in sedentary overweight adults asked not to change their diet, raising exercise energy expenditure produced dose-dependent loss of body mass and fat mass (high-amount group -2.9 kg body mass, -4.8 kg fat mass) while the non-exercising controls gained both. doi 10.1001/archinte.164.1.31 · PMID 14718319
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.