Supports the optic nerve
You want this restrained. Damage is irreversible. Regular eye examination is the only early detection.
In depth
Glaucoma — progressive loss of retinal ganglion cells and optic nerve fibers. Damage often goes undetected until sight is permanently gone.
What drives it
Eye pressure increases it.
Intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma and all licensed treatments lower IOP. However, many patients continue to lose vision despite IOP-lowering treatment. PMC11451402
Neuronal overexcitation increases it.
multiple interrelated mechanisms, including vascular dysregulation, oxidative stress, immune-inflammatory activation, excitotoxicity, and mitochondrial dysfunction, are implicated in RGC injury. PMC12608359
Mitochondrial energy reduces it.
multiple interrelated mechanisms, including vascular dysregulation, oxidative stress, immune-inflammatory activation, excitotoxicity, and mitochondrial dysfunction, are implicated in RGC injury. PMC12608359
Oxidative stress increases it.
multiple interrelated mechanisms, including vascular dysregulation, oxidative stress, immune-inflammatory activation, excitotoxicity, and mitochondrial dysfunction, are implicated in RGC injury. PMC11451402 Verbatim: “Although lowering intraocular pressure (IOP) is the only proven prevention and therapy, multiple interrelated mechanisms, including vascular dysregulation, oxidative stress, immune-inflammatory activation, excitotoxicity, and mitochondrial dysfunction, are implicated in RGC injury”. doi 10.3390/nu17213369 · PMC11451402
Supports young eyes increases it.
Key risk factors for glaucoma include elevated IOP, genetic predisposition, high myopia, and certain systemic conditions such as hypertension and cardiovascular disease. PMC11289249
Insulin sensitivity reduces it.
Accumulated evidence has demonstrated a strong relationship between IR and a higher incidence of several dramatically vision-threatening retinal diseases, including diabetic retinopathy, age-related macular…. 10.3389/fendo.2024.1415521. doi 10.3389/fendo.2024.1415521
What it drives
It reduces Vision.
Glaucoma, a leading cause of irreversible vision loss, is characterized by progressive degeneration of retinal ganglion cells. PMC12608359
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.