Spermidine
Spermidine triggers autophagy, the cell's housekeeping, and keeps the melanocyte stem cells of the hair bulb active enough to refill each strand with pigment.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
In immune cells taken from donors over 65 and treated in the lab, spermidine restored the autophagy clear-out that had slowed with age.
Named for semen, found in wheat germ and aged cheese: spermidine renews muscle cells through autophagy, preserving strength and fiber as years pass.
Human population data links higher intake to lower mortality.
Spermidine, a polyamine autophagy inducer, retarded senescence of human stem cells (SA-β-gal and ROS down) via SIRT3; an early human trial reported reduced immune-cell senescence with lower lymphocyte p16.
A molecule every cell makes and makes less of with age — it restarts the recycling process that breaks down worn parts and builds anew from them.
Where it appears
6 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- Autophagy Activator (Cellular Self-Renewal)
- Endurance Eternal (Pigment Preservation)
- Gainz (Muscle, Strength & Recovery)
- Hormesis (Adaptive Stress Conditioning)
- Senolytic (Senescent Zombie Cell Clearance)
- Victorious (Antiviral Immunity)