Honokiol (magnolia bark)
Magnolia officinalis
Picks the abnormal cells over its neighbor: honokiol killed two lines of abnormal human bone cells at a third to a seventh of what ordinary connective-tissue cells withstood, by a burst of reactive oxygen — mop the oxygen up and the killing stops.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
Honokiol, from magnolia bark, prevented diet-driven fat-cell formation by lowering C/EBP-alpha in visceral fat.
Honokiol, the biphenyl of magnolia bark, drove strong autophagy in cells and raised the autophagy marker LC3B-II in treated mice.
Honokiol (from Magnolia) reduced cellular senescence in microglia, lowering SA-β-gal, p21 and neuroinflammatory signaling.
From magnolia bark, a neolignan that slips through membranes and quiets the transcription switch that drives inflammation from within the cell.
Magnolia bark’s magnolol cut jawbone resorption, the bone-dissolving osteoclasts and the RANKL signal that summons them.
Where it appears
4 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ACB (Cell-Cycle Checkpoint Restraint)
- Anti-Adipogenic (Preadipocyte Arrest)
- Senolytic (Senescent Zombie Cell Clearance)
- Victorious (Antiviral Immunity)