Capsaicin (Chili pepper extract)
Capsicum annuum
Over twelve weeks against placebo, capsaicinoids cut how much volunteers ate by up to 257 calories a day.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
The TRPV1 agonist that recruits metabolic and vasodilatory pathways — human data on lipid handling and endothelial tone.
Capsaicin blocks the inflammatory alarm two steps upstream of the alarm itself, and lowered the same signaling in infected mice.
Three pooled analyses: resting energy use up about 34 calories a day, with fuel shifted toward fat.
Chili's heat compound reaches the droplet down a road the adrenaline messenger never travels - a sensory calcium channel.
Capsaicin binds KEAP1 itself — the protein that holds NRF2 captive — cutting the pair apart by about half and freeing the defense genes in human stomach cells.
Chili capsaicin activates TRPV1 thermogenesis; controlled trials show it raises energy expenditure and fat oxidation and lowers body weight — burning off the fat obesogens promote.
Raises resting metabolism about 34 kcal a day over placebo across 13 trials, tipping fuel use toward fat.
In a double-blind, placebo-controlled crossover trial, capsinoids from sweet pepper raised resting oxygen use and shifted the body toward burning fat at rest.
Where it appears
8 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- Appetite Suppressant (Hunger Signal Control)
- EKG Cardioprotective (Contractile Reserve)
- Helico (Gastric Colonization Defense)
- Holy Grail (Fat Leaves As Breath)
- Spice (Anti-Inflammatory Polyphenol Powerhouse)
- Lipolytic (Stored-Fat Mobilization)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Thermo (Thermogenic Disposal)