Baicalein
Scutellaria baicalensis
Skullcap's baicalein damps the swelling switch and the inflammasome's fire at their root, and turns on antioxidant defense in the stressed brain.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
In laboratory tests, baicalein from Baikal skullcap stopped tau from forming fibrils and broke up amyloid-beta fibrils, the two proteins that clump in the aging brain.
Skullcap's baicalein opens the antioxidant gene program in animals the indirect way.
Push the brain's support cells into premature aging with oxidative stress and baicalein delays the slide, damping the inflammatory chatter that normally follows.
Skullcap root's golden flavone holds the inflammatory switch closed and flicks the antioxidant one open — two levers pulled in a single motion.
One of only three actives among fifty traditional herbs put through the same test — and the forty-seven failures are the reason the three are believable.
In human cells, baicalein, the yellow flavone of Scutellaria root, halted abnormal bladder cells at two checkpoints, shut down their NF-kappaB survival signal and cut invasion.
In diabetic mice and kidney cells it restores the autophagy that high blood sugar had shut down.
Where it appears
5 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- ALZ (Memory Preservation)
- Event Horizon (Post-Ethanol Restoration)
- NRF2 Activator (Endogenous Antioxidant Induction)
- Senolytic (Senescent Zombie Cell Clearance)
- Victorious (Antiviral Immunity)