Plaque clearance
Amyloid-β aggregation↓
Also searched as Amyloid-β aggregation.
In depth
Amyloid-β accumulation — the pathology that defines Alzheimer's disease alongside tau. Detectable by PET and now by blood tests (plasma p-tau217) decades before symptoms.
What drives it
Brain inflammation increases it.
10.3389/fimmu.2023.1117172 — 对AD患者和对照组的尸检结果表明，在AD患者的大脑中观察到小胶质细胞的活化，并且与无斑块的皮质区相比，Aβ斑块内的小胶质细胞活化程度明显更高. Verbatim from the source for this edge — no-separate-source: reading of the g2 sources (正文 / body). doi 10.3389/fimmu.2023.1117172
What it drives
It increases Tau tangles.
10.3389/fnagi.2020.00265 — amyloid-beta triggers the aggregation and spreading of tau pathology; regions with greater A-beta burden show greater tau than predicted by connectivity patterns. Verbatim from the source for this edge — no-separate-source: reading of the g2 sources (abstract). doi 10.3389/fnagi.2020.00265
It reduces Memory & focus.
PMC13248426 — isolated evaluation of amyloid burden demonstrates minimal association with specific domains of cognitive function; amyloid plaques appear to have only subtle effects on cognition and brain health in humans, if any. Verbatim from the source for this edge — no-separate-source: reading of the g2 sources (discussion / introduction). PMC13248426
It reduces Unprompted recall.
Verbatim: 'Episodic memory was assayed using a standardized delayed recall composite, paired associate (word-picture) cued recall, and a mnemonic discrimination task' (10.1212/WNL.0000000000003812, 10.1212/WNL.0000000000011477, PMC12782246). Tier: human cohort data (cross-sectional + longitudinal). cognitively unimpaired / clinically normal older adults - the preclinical stage, not dementia; amyloid by CSF Abeta42/40 or PET SUVR; endpoi. doi 10.1212/WNL.0000000000003812 · PMC12782246
It reduces Recall with a hint.
Verbatim: 'Abeta+ participants were 3.55 times (95% confidence interval = 1.77-7.12) more likely to exhibit decline in total recall' (10.1212/WNL.0000000000003812, 10.1212/WNL.0000000000011477). Tier: human longitudinal cohort data. clinically normal older adults (preclinical stage), amyloid measured by PET, endpoint Free and Cued Selective Reminding Test total recall over 3 years. Stops: c. doi 10.1212/WNL.0000000000003812
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.