Tau tangles
Phosphorylated tau accumulation↓
Also searched as Phosphorylated tau accumulation.
In depth
Phosphorylated tau accumulation — the second defining Alzheimer's pathology. Plasma p-tau217 and p-tau231 track it and rise very early. Tau tracks cognitive decline more tightly than amyloid does.
What drives it
Plaque clearance increases it.
10.3389/fnagi.2020.00265 — amyloid-beta triggers the aggregation and spreading of tau pathology; regions with greater A-beta burden show greater tau than predicted by connectivity patterns. Verbatim from the source for this edge — no-separate-source: reading of the g2 sources (abstract). doi 10.3389/fnagi.2020.00265
What it drives
It reduces Memory & focus.
10.1007/s00401-024-02839-2 — tau neurofibrillary tangles are strongly correlated with local neurodegeneration and, in turn, cognitive impairment; the propagation and spreading of CNS tau pathology closely correlates with cognitive decline. Verbatim from the source for this edge — no-separate-source: reading of the g2 sources (introduction). doi 10.1007/s00401-024-02839-2
It reduces Unprompted recall.
Verbatim: 'There was an association between decreased visuospatial delayed memory performance and p-Tau level (B = − 0.754, β = − 0.363, p 0.001), independent of other relevant variables (e.g., Aβ).' (10.1186/s13195-021-00909-1). Tier: human observational data. human · lumbar CSF sampling, no dosing · Gwangju Alzheimer's Disease and Related Dementia Cohort, Korea · n = 185 (93 A-T-, 23 A+T-, 69 A+T+) · cross-sectional observational, m. doi 10.1186/s13195-021-00909-1
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.