What is behind Autoimmune & Inflammation
The master inflammatory switch — indispensable to defend against threat, corrosive when it never stands down. Evidence B — Preclinical.
The NLRP3 inflammasome — a sensor of cellular stress that ignites sterile, damage-driven inflammation. Evidence A — Human trial evidence.
The transcription factor that commands the body's own antioxidant and detoxification arsenal. Evidence A — Human trial evidence.
The intestinal barrier — the selective wall that admits nutrients, excludes toxins and anchors the gut–brain and immune dialogue. Evidence B — Preclinical.
IL-17 signaling — a cytokine that guards mucosal surfaces yet, dysregulated, drives autoimmune inflammation. Evidence B — Preclinical.
Immune surveillance — the standing patrol that detects and clears pathogens and aberrant cells. Evidence A — Human trial evidence.
Immune modulation — the calibrated restraint that keeps the defense system from turning on the self. Evidence A — Human trial evidence.
Evidence on these pathways
Intestinal Barrier → Ammonia. “This weakens the paracellular seal of the intestinal epithelium, enabling microbial products such as endotoxins, ammonia, and even whole microorganisms to translocate into the portal circulation.” — How the gut-liver axis shapes hepatic encephalopathy: mechanistic and therapeutic perspectives. Exploration of Digestive Diseases 2025;4:100597. doi:10.37349/edd.2025.100597 (no PMID exists — the journal is not MEDLINE-indexed; absence confirmed on file, not derived)
Intestinal Barrier → Oxygen-Carrying Capacity. “The two main causes are the villous atrophy of the mucosa at the site of iron absorption (the duodenum) and the resulting inflammation, which triggers the mechanism that leads to the anemia of chronic disease.” — Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet. Nutrients, 2020, 12(8), 2176. doi:10.3390/nu12082176
Intestinal Barrier → Micronutrient Status. “Micronutrient deficits, such as those in zinc and iron, can be caused by intestinal permeability and gut inflammation brought on by environmental enteric dysfunction.” — Environmental Enteropathy and Anaemia Status Among Under-Five Children, in Slum Areas of Jimma Town, Ethiopia. Pediatric Health, Medicine and Therapeutics, 2023, vol 14, 33-43. doi:10.2147/PHMT.S387747
Immune Surveillance → Infection Resistance. “Primary Immunodeficiencies (PID) are genetically inherited disorders characterized by defects of the immune system, leading to increased susceptibility to infection.” — Diagnostics of Primary Immunodeficiency Diseases: A Sequencing Capture Approach. PLoS ONE, 2014, volume 9, e114901. doi:10.1371/journal.pone.0114901
Formulas that act on these pathways
Acts on 7 of these pathways: NF-κB, NLRP3 Inflammasome, Nrf2, Intestinal Barrier, IL-17 Signaling, Immune Surveillance, Immune Modulation.
Acts on 6 of these pathways: NF-κB, NLRP3 Inflammasome, Nrf2, Intestinal Barrier, IL-17 Signaling, Immune Surveillance.
Acts on 6 of these pathways: NF-κB, NLRP3 Inflammasome, Nrf2, Intestinal Barrier, IL-17 Signaling, Immune Modulation.
Acts on 5 of these pathways: NF-κB, NLRP3 Inflammasome, Nrf2, IL-17 Signaling, Immune Surveillance.
Acts on 5 of these pathways: NF-κB, Nrf2, Intestinal Barrier, IL-17 Signaling, Immune Surveillance.
Acts on 5 of these pathways: NF-κB, NLRP3 Inflammasome, Nrf2, IL-17 Signaling, Immune Modulation.
What this page does not claim
This page names the pathways involved and the published evidence on each. It does not claim that any formula treats, cures or prevents Autoimmune & Inflammation. A pathway opens here only on graded, published evidence, under a standard fixed before the evidence was gathered, and every figure above carries its grade.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.