Withanolides (Ashwagandha)
Withania somnifera
Ashwagandha root lowers cortisol and eases the stress axis's grip, so tension no longer runs the day and calm returns at night.
What the evidence shows
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Lowers cortisol, raises thyroid hormone in subclinical hypothyroidism, and raises testosterone while cutting body fat.
The withanolide-rich leaf raised both lipases and the browning machinery, cutting stored fat inside the cell to 41.58%.
The adaptogenic keystone — withanolides lower the cortisol that suppresses the reproductive axis while human randomized trials report gains in sperm count, motility and testosterone.
The withanolide-rich leaf raised both lipase genes and the browning genes, cutting stored fat inside the cell to 41.58%.
Across 9 randomized trials and 558 people, lowered perceived stress, anxiety scores and cortisol against placebo.
Where it appears
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