Monocyte recruitment
MCP-1 monocyte recruitment↓
Also searched as MCP-1 monocyte recruitment.
The cell that shouts this loudest is not the muscle cell — it is the one that will later lay down scar. So the same cell recruits the inflammation and then paves over the damage it helped cause.
In depth
The signal that recruits more inflammatory cells into the heart.
What drives it
Heart muscle inflammation increases it.
The signal that calls in the reinforcements — and the scar cell shouts it loudest. Myricetin ameliorates the disease 'by modulating immune response and inhibiting MCP-1 expression' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting mcp-1 expression). And the source matters: 'the expression of TNF-α, IL-6, MCP-1, and IFN-β was significantly increased in cardiac fibroblasts compared to cardiomyocytes or macrophages' (pmc4211177 — Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication). ⇒ the cell that will later lay down the scar is also the loudest caller-in of inflammation. doi 10.1016/j.ejphar.2023.175551
Cardiac scarring cells increases it.
The signal that calls in the reinforcements — and the scar cell shouts it loudest. Myricetin ameliorates the disease 'by modulating immune response and inhibiting MCP-1 expression' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting mcp-1 expression). And the source matters: 'the expression of TNF-α, IL-6, MCP-1, and IFN-β was significantly increased in cardiac fibroblasts compared to cardiomyocytes or macrophages' (pmc4211177 — Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication). ⇒ the cell that will later lay down the scar is also the loudest caller-in of inflammation. doi 10.1016/j.ejphar.2023.175551
What it drives
It increases Heart muscle inflammation.
The signal that calls in the reinforcements — and the scar cell shouts it loudest. Myricetin ameliorates the disease 'by modulating immune response and inhibiting MCP-1 expression' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting mcp-1 expression). And the source matters: 'the expression of TNF-α, IL-6, MCP-1, and IFN-β was significantly increased in cardiac fibroblasts compared to cardiomyocytes or macrophages' (pmc4211177 — Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication). ⇒ the cell that will later lay down the scar is also the loudest caller-in of inflammation. doi 10.1016/j.ejphar.2023.175551
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.