Metabolic health
You want it healthy: sound metabolic tone is the quiet engine of long-term wellness. Note this is the summary node — Glycemic Load, Insulin Sensitivity and Lipid Metabolism are the specific ones, each with its own drivers.
In depth
The aggregate handling of fuel — glucose, fat and the hormones that route them, taken as one picture.
What drives it
Fat-burning hormone increases it.
Adiponectin/insulin-sensitivity review 2003 — adiponectin increases muscle glucose uptake and fat oxidation and reduces hepatic glucose production (via AMPK), improving whole-body insulin sensitivity and glycemic control. PMID 12769732
Trauma symptoms reduces it.
A meta-analysis of 9 studies and over 9,000 subjects found people with PTSD had almost doubled risk for comorbid metabolic syndrome; PTSD symptom severity predicts risk in a fashion. doi 10.31083/RCM44081 · PMC11065026
Heat instead of storage increases it.
n=4,011: BAT-positive subjects had lower fasting glucose and triglycerides (both P<0.01) and increased HDL (P<0.0001). n=1,702: BAT+ showed lower T2DM prevalence (6.1% vs 10.4%, p=0.0012), lower blood…. PMC4403996
What it drives
It reduces Lowers uric acid.
Insulin/urate-transport study 2017, Am J Physiol Renal — hyperinsulinemia/insulin resistance reduces renal uric-acid excretion (raising URAT1, lowering ABCG2); improved insulin sensitivity restores excretion, lowering serum urate. doi 10.1152/ajprenal.00012.2017
It increases Heart & blood pressure.
Hyperglycemia/CV review 2013, Diabetes Care — chronic hyperglycemia (glucotoxicity) drives oxidative stress and endothelial dysfunction, contributing to macrovascular/cardiovascular disease. PMC3632149
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.