Growth driver
c-Myc regulation
Also searched as c-Myc regulation.
You want it restrained: enough to renew tissue, never enough to run away.
In depth
A master proliferation network that drives cell growth and metabolic throughput — powerful for renewal, dangerous in overdrive.
What drives it
Cell fate signaling increases it.
Palomero 2006, PNAS — NOTCH1 directly induces c-MYC gene expression, making c-MYC an essential mediator of NOTCH1 growth signaling. doi 10.1073/pnas.0606108103
What it drives
It increases Cell division control.
Myc/cell-cycle study 2019, Sci Rep — c-Myc drives G1→S progression by transactivating cyclins (D2, A, E), repressing CDK inhibitors (p15/p21) and degrading p27. doi 10.1038/s41598-019-54917-1
It increases Sugar burning.
Osthus & Dang 2000, J Biol Chem — c-Myc directly transactivates glycolytic genes (GLUT1, PFK, enolase, LDHA), driving glucose uptake and the Warburg shift. PMID 10823814
It increases Cell turnover.
Thus, Myc transduces a potent mitogenic stimulus but, concomitantly, induces apoptosis in the absence of survival factors. PMID 9468463
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.