Cell fate signaling
Notch signaling
Also searched as Notch signaling.
You want it balanced: right for tissue maintenance, restrained against aberrant growth.
In depth
Notch signaling — the arbiter of cell identity and tissue patterning, pivotal in renewal and miswired in disease.
What drives it
Calms inflammation increases it.
NF-κB/Notch1 study 2017, Sci Rep — NF-κB-dependent activation of the Notch1 gene (and induction of its ligand Jagged1) drives Notch signaling in inflamed tissue. doi 10.1038/s41598-017-06750-7
What it drives
It increases Growth driver.
Palomero 2006, PNAS — NOTCH1 directly induces c-MYC gene expression, making c-MYC an essential mediator of NOTCH1 growth signaling. doi 10.1073/pnas.0606108103
It increases Cell migration switch.
EMT-and-invasion review 2013 — Notch signaling activates Snail/Slug/ZEB repressors of E-cadherin, driving epithelial-to-mesenchymal transition. PMID 24278531
It increases Bone health.
Named across six reviews of bone remodeling and osteoarthritis pathogenesis. Bone remodeling relies on the coordinated actions of bone-resorbing osteoclasts, bone-forming osteoblasts, and osteocytes serving as mechanosensors and local remodeling coordinators. PMC10648156
It reduces Calms inflammation.
Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. 10.1038/labinvest.3700700. doi 10.1038/labinvest.3700700
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.