Cell division control
Cell-cycle control
Also searched as Cell-cycle control.
You want renewal where needed and arrest where warranted: a working checkpoint guards against both cancer and premature senescence.
In depth
The cyclin–cdk–rb checkpoint that decides whether a cell may divide — the brake on uncontrolled proliferation.
What drives it
Growth driver increases it.
Myc/cell-cycle study 2019, Sci Rep — c-Myc drives G1→S progression by transactivating cyclins (D2, A, E), repressing CDK inhibitors (p15/p21) and degrading p27. doi 10.1038/s41598-019-54917-1
What it drives
It increases Clears worn-out cells.
Serrano 1997, Cell 88:593 — p16-INK4a inhibits CDK4/6, holding RB active for the G1 arrest that defines senescence. PMID 9054499
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.