Clot breakdown
You want it capable: brisk fibrinolysis guards against a dense, dangerous clot burden.
In depth
Fibrinolysis — the clot-dissolving system that keeps blood flowing and clears intravascular fibrin.
What drives it
Calms inflammation reduces it.
Swiatkowska 2005 — TNF-α/ROS induces PAI-1 (the primary inhibitor of fibrinolysis) via NF-κB binding the PAI-1 promoter; a super-suppressor IκBα abolishes it. PMID 16279946
Lipid messengers reduces it.
Thromboxane A2 drives platelet aggregation - the aspirin target. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
Vitamin K status increases it.
The classical coagulation role - factors II, VII, IX and X are Gla proteins. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
What it drives
It increases Heart & blood pressure.
Fibrin/CVD review 2023, Cardiovasc Res 119:94 — plasmin-mediated fibrinolysis dissolves intravascular fibrin/thrombi; impaired fibrinolysis (high PAI-1, dense clots) predicts adverse cardiovascular events. PMC10377755
It reduces Clot formation.
The counter-force. Verbatim: 'Endogenous fibrinolysis is an important physiological countermeasure against development and lasting arterial or venous thrombosis' (PMC7867291). Physiological — laboratory measures, not a supplement trial. PMC7867291
It increases Wound healing.
The one measured finding among them is the periodontal-anemia link: a meta-analysis of sixteen studies on hemoglobin and iron metabolism in periodontitis, whose authors call the association still controversial and ask for larger cohorts. doi 10.1152/japplphysiol.00971.2016 · PMC7005133
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.