What is behind Skin Anti-Aging & Wrinkles
Tissue structure and remodeling. Evidence A — Human trial evidence.
The transcription factor that commands the body's own antioxidant and detoxification arsenal. Evidence A — Human trial evidence.
Advanced glycation end-products — the sugar-damaged proteins that stiffen tissue and inflame the vessel wall. Evidence A — Human trial evidence.
The body's largest organ and its most visible record. Collagen, elastin and barrier lipids degrade on a measurable schedule — and the evidence shows the degradation mechanisms specifically, because that is what the evidence actually witnesses. Evidence A — Human trial evidence.
Evidence on these pathways
Nrf2 → Detoxification & Clearance. “NRF2-induced expression of ARE-containing cytoprotective genes in response to cell stress forms a network of cooperating enzymes involved in phase I, II, and III drug detoxification reaction and elimination of pro-oxidants to maintain cellular homeostasis.” — NRF2, a Transcription Factor for Stress Response and Beyond. International Journal of Molecular Sciences, 2020, vol 21(13), 4777. doi:10.3390/ijms21134777
Nrf2 → Atopic Dermatitis. “In addition, we found that the production of Th2 cytokines is negatively regulated by NRF2, and the induction of NRF2 by cardamonin contributed to suppressing oxazolone-induced Th2 cytokine production and oxidative damages in vivo.” — Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production. Antioxidants 2020;9(9):834. doi:10.3390/antiox9090834
Formulas that act on these pathways
Acts on 3 of these pathways: Nrf2, Advanced Glycation (AGEs), Skin Structure & Barrier.
Acts on 2 of these pathways: Nrf2, Skin Structure & Barrier.
Acts on 2 of these pathways: Nrf2, Advanced Glycation (AGEs).
What this page does not claim
This page names the pathways involved and the published evidence on each. It does not claim that any formula treats, cures or prevents Skin Anti-Aging & Wrinkles. A pathway opens here only on graded, published evidence, under a standard fixed before the evidence was gathered, and every figure above carries its grade.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.