What is behind IBS & Bowel Regularity
The intestinal barrier — the selective wall that admits nutrients, excludes toxins and anchors the gut–brain and immune dialogue. Evidence B — Preclinical.
The master inflammatory switch — indispensable to defend against threat, corrosive when it never stands down. Evidence B — Preclinical.
Immune surveillance — the standing patrol that detects and clears pathogens and aberrant cells. Evidence A — Human trial evidence.
Serotonin — the neurotransmitter of mood and satiety, and the precursor the body converts to melatonin for sleep. Evidence A — Human trial evidence.
Gastrointestinal function — the comfort and efficiency of digestion and nutrient absorption.
Evidence on these pathways
Digestive Function → Infection Resistance. “NFκB activation by IECs limits candidalysin-mediated host-cell damage and mediates maintenance of the intestinal barrier and cell-cell junctions to further restrict fungal translocation.” — Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection. PLoS Pathogens; 2024; volume 20; page/elocation not printed on either retrieved record. doi:10.1371/journal.ppat.1012031
Intestinal Barrier → Ammonia. “This weakens the paracellular seal of the intestinal epithelium, enabling microbial products such as endotoxins, ammonia, and even whole microorganisms to translocate into the portal circulation.” — How the gut-liver axis shapes hepatic encephalopathy: mechanistic and therapeutic perspectives. Exploration of Digestive Diseases 2025;4:100597. doi:10.37349/edd.2025.100597 (no PMID exists — the journal is not MEDLINE-indexed; absence confirmed on file, not derived)
Intestinal Barrier → Oxygen-Carrying Capacity. “The two main causes are the villous atrophy of the mucosa at the site of iron absorption (the duodenum) and the resulting inflammation, which triggers the mechanism that leads to the anemia of chronic disease.” — Persistent Iron Deficiency Anemia in Patients with Celiac Disease Despite a Gluten-Free Diet. Nutrients, 2020, 12(8), 2176. doi:10.3390/nu12082176
Intestinal Barrier → Micronutrient Status. “Micronutrient deficits, such as those in zinc and iron, can be caused by intestinal permeability and gut inflammation brought on by environmental enteric dysfunction.” — Environmental Enteropathy and Anaemia Status Among Under-Five Children, in Slum Areas of Jimma Town, Ethiopia. Pediatric Health, Medicine and Therapeutics, 2023, vol 14, 33-43. doi:10.2147/PHMT.S387747
Formulas that act on these pathways
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Immune Surveillance, Serotonin.
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Serotonin, Digestive Function.
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Immune Surveillance, Serotonin.
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Immune Surveillance, Digestive Function.
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Immune Surveillance, Serotonin.
Acts on 4 of these pathways: Intestinal Barrier, NF-κB, Immune Surveillance, Digestive Function.
What this page does not claim
This page names the pathways involved and the published evidence on each. It does not claim that any formula treats, cures or prevents IBS & Bowel Regularity. A pathway opens here only on graded, published evidence, under a standard fixed before the evidence was gathered, and every figure above carries its grade.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.