Salidroside (Rhodiola)
Rhodiola rosea
Salidroside, the marker compound of rhodiola, raises SIRT1 across several animal organ-injury models.
What the evidence shows
Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.
Arctic rhodiola's salidroside turns down the HPA alarm, blunting the cortisol surge so pressure registers but no longer overwhelms.
Salidroside, the active drawn out of Rhodiola rosea, hits the recycling switch from both sides at once - waking the energy sensor and quieting the growth hub.
In mice on a high-fat diet, salidroside lowered obesity, blood-sugar swings and liver fat, and raised insulin sensitivity markedly.
It switches on the NRF2 antioxidant response, the heat-shock proteins and AMPK — the adaptive stress responses in full — and does so dose-dependently in living animals.
When cortisol runs high and long, salidroside eases the alarm line between brain and adrenal gland, so stress rises less and ebbs sooner.
Rhodiola's salidroside has been put through three unrelated animal challenges - fat-fed obesity, lung injury and stroke - and the same antioxidant response appears in each.
Where it appears
6 blend pages carry this ingredient. Open it and you will find this ingredient in the list.
- Autonomous (Executive Command)
- Autophagy Activator (Cellular Self-Renewal)
- Ceramide Blocker (Lipotoxicity Neutralizer)
- Hormesis (Adaptive Stress Conditioning)
- NAD+ Booster (Cellular Energy Currency)
- NRF2 Activator (Endogenous Antioxidant Induction)