Vitamin E status
Works inside membranes and lipoproteins where water-soluble antioxidants cannot reach, and is regenerated by ascorbate. High-dose supplementation trials have generally disappointed, which is the standard caution against treating a mechanism as an outcome.
In depth
Alpha-tocopherol — the principal lipid-phase chain-breaking antioxidant.
What drives it
Micronutrient status increases it.
Dietary vitamin E. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
Vitamin C increases it.
Ascorbate regenerates oxidized tocopherol at the membrane surface. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
What it drives
It reduces Oxidative stress.
The principal lipid-phase chain-breaking antioxidant. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
It increases Vision.
A protective effect of high plasma alpha-tocopherol on macular disease was described as convincingly demonstrated. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.