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Pathway

The Story Of Your Life

In depth

A subdomain of learning and memory: recalling your own past events. Splits further into episodic detail (fornix/hippocampus) and semantic self-knowledge (anterior temporal lobe) — two dissociable tracts.

What drives it

Mood increases it.

people with remitted depression recalled fewer specific memories (k = 15; g = -0.314, 95% CI [-0.543; -0.085], z = -2.69, p =.007) and more categoric memories (k = 9; g = 0.254, 95% CI [0.007; 0.501], z = 2.02, p =.043) compared to people who had never been depressed. Verbatim from the source for this edge —. PMC9828164

What it drives

It increases Learning & memory.

The DSM-5 Neurocognitive Work Group agreed on six principal domains of cognitive function, each with subdomains. Learning and memory comprises immediate memory, recent memory (free recall, cued recall and recognition memory), and very-long-term memory including semantic, autobiographical and implicit learning. Taxonomic edge, not a causal mechanism: this is a DSM-5 domain/subdomain relationship, not a pathway acting on another. Sachdev 2014, Nat Rev Neurol 10:634-642 — Classifying neurocognitive disorders: the DSM-5 approach. doi 10.1038/nrneurol.2014.181 The manual's own table, which carries the immediate/recent nesting this line states, is reproduced verbatim as 'Immediate memory, recent memory' in Table 1 of doi 10.1186/s13643-019-1220-4 (Domains used to diagnose major and mild neurocognitive disorders in the DSM-5). Scope stated before anyone asks: Sachdev's Figure 2 is an ABRIDGED rendering of the DSM-5 table and does not carry every subdomain named here, so the manual's own wording is cited beside it. doi 10.1038/nrneurol.2014.181

It increases Word & fact memory.

23536058 — Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs – independent of memory age. PMC5576916

It increases Mood.

Fewer specific memories and more categoric/overgeneral memories were associated with higher follow-up depressive symptoms, and predicted higher follow-up symptoms over and above initial symptoms. Verbatim from the source for this edge — PMID 33875023. PMID 33875023

See it on the map

Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.

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