Riboflavin cofactor
FAD/FMN electron carriers
Also searched as FAD/FMN electron carriers.
MTHFR is a flavoprotein. The enzyme at the center of the methylation conversation requires FAD, so riboflavin status modifies the effect of the mthfr variants people test for — and the variant most discussed is the one that destabilizes the FAD cofactor.
In depth
Riboflavin-derived FAD and fmn — electron carriers for a large set of oxidoreductases.
What drives it
Micronutrient status increases it.
10.1016/j.afres.2025.101480 — Dietary riboflavin. Carried by the intermediary-metabolism, micronutrient and redox reviews. doi 10.1016/j.afres.2025.101480 · PMC9967593
What it drives
It increases One-carbon metabolism.
MTHFR is A FLAVOPROTEIN - riboflavin status modifies the effect of the MTHFR variants people test for, and the variant most discussed is the one that destabilizes the FAD cofactor. Carried by the intermediary-metabolism, micronutrient and redox reviews. doi 10.3390/nu18132141 · PMC9967593
It increases Mitochondrial energy.
Complex I and II are flavoproteins. Carried by the intermediary-metabolism, micronutrient and redox reviews. doi 10.3390/nu18132141 · PMC9967593
It increases Fat burning.
Acyl-CoA dehydrogenases are FAD-dependent. Carried by the intermediary-metabolism, micronutrient and redox reviews. doi 10.3390/nu18132141 · PMC9967593
It reduces Neurovascular calm.
Riboflavin, which improves mitochondrial energy metabolism, is effective in migraine prophylaxis; it is the precursor of FMN and FAD, essential components of complexes I and II of the electron transport chain. doi 10.1186/s10194-015-0516-6 · PMID 15728298 · PMC7786797
Blends that modulate it
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See it on the map
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