Nitrogen clearance
The Point at Which Liver Failure Becomes a brain problem. Ammonia is neurotoxic and the liver is the only organ that clears it at scale. Arginine and ornithine are intermediates of this cycle.
In depth
The hepatic cycle converting ammonia to urea for excretion.
What drives it
Liver increases it.
The urea cycle is hepatic and the liver is the only organ that clears ammonia at scale. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
Nitric oxide precursor increases it.
The urea cycle substrate. Carried by the intermediary-metabolism, micronutrient and redox reviews. doi 10.3390/nu18132141 · PMC9967593
What it drives
It increases Memory & focus.
The point at which liver failure becomes a brain problem. Ammonia is neurotoxic. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
It increases Blood flow (nitric oxide).
Arginine is a urea-cycle intermediate and the substrate for nitric oxide synthase. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
It reduces Kidney.
Renal excretion completes nitrogen disposal. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
Blends that reach it upstream
Each of these acts on a pathway that feeds this one. The step is named beneath the blend, and that pathway carries the study behind it.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.