Mitochondrial pore
Mitochondrial pore (mPTP)
Also searched as Mitochondrial pore (mPTP).
You want it kept shut. Stated plainly: the best pharmacological test of this idea failed in humans — cyclosporine A, a cyclophilin-D inhibitor, did not protect the heart in a large myocardial-infarction trial. And mice lacking cyclophilin D entirely develop adult-onset obesity. The three botanicals here were measured on pore opening in animal and cell models; none has a human outcome behind it.
In depth
The mitochondrial permeability transition pore — a channel that opens when a mitochondrion is overloaded with calcium and oxidative stress. Once it opens wide, the membrane potential collapses and the cell dies.
What drives it
Mitochondrial oxidant leak increases it.
10.1038/s41418-023-01187-0 — Oxidative stress and a calcium overload together prise open the pore: cyclophilin D moves to the inner membrane under high matrix calcium, and the channel opens. doi 10.1038/s41418-023-01187-0
What it drives
It reduces Mitochondrial energy.
10.1038/s41418-023-01187-0 — Once the pore opens the membrane potential collapses — measured by confocal microscopy and high-resolution respirometry in a pulmonary-hypertension model, where the compromised energetics degraded heart-muscle function. Verbatim: “PAH significantly affects mitochondrial function in RV; PAH is prone to mitochondrial permeability transition pore (mPTP) opening, thus decreasing the mitochondrial membrane potential”. doi 10.1038/s41418-023-01187-0 · PMID 34239697 · PMC8238598
It increases Cell turnover.
10.1038/s41418-023-01187-0 — Ginsenoside Rb1 protected heart cells from dying specifically by keeping this pore shut — the protection tracked the pore, not a general antioxidant effect. the reference drug for this target failed to protect the heart in a large human trial. doi 10.1038/s41418-023-01187-0
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.