Mitochondrial DNA
Mitochondrially encoded energy-chain subunits
Also searched as Mitochondrially encoded energy-chain subunits.
Mitochondria carry their own small genome, encoding thirteen essential parts of the energy-production chain. It sits close to where damaging by-products are made and has less repair machinery than nuclear DNA, so it takes damage first — and when it does, energy production falls.
In depth
The small genome inside mitochondria that encodes thirteen essential parts of the energy chain.
What drives it
Mitochondrial energy increases it.
Mitochondrial dysfunction is accompanied by loss of mitochondrial DNA integrity and accumulation of mtDNA mutations. doi 10.1016/j.cell.2022.11.001 · PMID 23746838 · PMC7139312
Mitochondrial oxidant leak reduces it.
mtDNA lies adjacent to the inner membrane and is damaged by locally generated ROS. doi 10.1016/j.cell.2022.11.001 · PMID 23746838 · PMC7139312
Recycles mitochondria increases it.
Selective removal of damaged mitochondria preserves the integrity of the remaining genome pool. doi 10.1016/j.cell.2022.11.001 · PMID 23746838 · PMC7139312
What it drives
It increases Mitochondrial energy.
Mitochondrial DNA encodes 13 essential subunits of the electron transport chain; mtDNA damage and depletion impair oxidative phosphorylation. Intact mtDNA is a precondition for mitochondrial function, not an inhibitor of it. PMC5406601
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.