Lipid phosphatase
PGC-1alpha/PPARalpha coactivation
Also searched as PGC-1alpha/PPARalpha coactivation.
You want it working alongside PPARα: lipin-1 turns up the volume on the fat-oxidation signal.
In depth
The bifunctional coactivator that amplifies the pgc-1α/PPARα program, deepening the liver's commitment to fat-burning.
What drives it
Builds mitochondria increases it.
Lipin activates the PPARalpha/PGC-1alpha regulatory pathway via multiple mechanisms including cooperation with PPARalpha and PGC-1alpha as well as transcriptional activation of the PPARalpha gene... the expression of lipin 1 is induced by PGC-1alpha. doi 10.1016/j.cmet.2006.08.005 · PMID 16950137
What it drives
It increases Fat burning.
Finck 2006, Cell Metab 4:199 — lipin-1 is an inducible amplifier of the PGC-1α/PPARα pathway, potentiating fatty-acid-oxidation gene expression.
It increases Fatty-acid oxidation.
Lipin activates the PPARalpha/PGC-1alpha regulatory pathway via multiple mechanisms including cooperation with PPARalpha and PGC-1alpha as well as transcriptional activation of the PPARalpha gene... the expression of lipin 1 is induced by PGC-1alpha. doi 10.1016/j.cmet.2006.08.005 · PMID 16950137
It increases Diacylglycerol signaling.
Lipin-1 dephosphorylates phosphatidate to diacylglycerol, the physiological activator of conventional PKC. PMID 26658689
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.