Inflammatory fat substrate
Arachidonic acid
Also searched as Arachidonic acid.
The membrane is the reservoir. Arachidonic acid sits esterified in phospholipid until phospholipase A2 releases it — which is why membrane fatty-acid composition, set by diet over months, determines what is available to inflame with.
In depth
The omega-6 fatty acid released from membrane phospholipids on demand.
What drives it
Lowers cholesterol increases it.
Arachidonic acid sits esterified in membrane phospholipid until phospholipase A2 releases it. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
Omega-3 status reduces it.
Dietary EPA and DHA displace arachidonate from the membrane pool over months. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
What it drives
It increases Lipid messengers.
The 20-carbon substrate for cyclooxygenase and lipoxygenase. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
It increases Prostaglandin F2-alpha.
PGF2-alpha is an arachidonic-acid-derived prostanoid, formed from the COX pathway like every other prostaglandin including PGD2, like PGD2. Supplying the upstream so the shared origin of the opposing prostaglandins is visible: PGD2 and PGF2-alpha pull in opposite directions on hair from the same precursor pool. canonical biosynthesis, not an effect size, and no claim about any intervention shifting the ratio. Blume-Peytavi 2012 J Am Acad Dermatol. PMID 35289043
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.