Fat cell clearance
Fat-cell number↓
Also searched as Fat-cell number.
A fat cell can shrink and refill for years; a fat cell that is gone does not refill. Programmed death of mature adipocytes is the one route that lowers how many storage cells remain, rather than how full each one is. TNF-alpha triggers it in human adipose cells.
In depth
Adipocyte clearance — the controlled removal of a mature fat cell, which lowers fat-cell number rather than fat-cell size.
What drives it
Cell turnover increases it.
Based on the changes in the expression and activity of Bcl-2, Bax, cytochrome C, P53, and caspase-9, our results suggest that the intrinsic pathway plays an important role in the CLA-induced apoptosis of adipocytes. doi 10.1186/1746-6148-10-141
Lipolysis signal increases it.
We conclude that BMSO is effective in attenuating body fat accumulation through mechanisms associated with PKA activation and programmed cell death in the WAT. doi 10.3945/jn.112.159939
Fat-cell survival shield (p21) reduces it.
Thus, p21 is involved in both adipocyte differentiation and in protecting hypertrophied adipocytes against apoptosis. doi 10.1074/jbc.M801824200
Energy sensing increases it.
Activation of AMPK induced apoptotic cell death. doi 10.1016/j.bbrc.2005.11.159
Fat-tissue signal (TNF-α) increases it.
TNF-alpha induces apoptosis of human adipose cells. PMID 9392477
What it drives
It reduces Supports weight management.
Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick endlabeling (TUNEL) DNA fragmentation analysis revealed that fat-mass decrease by CLA was mainly due to apoptosis. doi 10.2337/diabetes.49.9.1534
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.