Candida burden

Commensal yeast that becomes a problem when the ecology shifts. The atlas flags a possible inverted sign on its periodontal edge — 21 of 23 studies found a positive association where the arrow is drawn inhibitory.

Gut barrier reduces it.

10.1186/s13099-025-00755-8 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “Current evidence indicates that probiotics can reduce the risk of Candida colonization in preterm neonates in NICUs”. doi 10.1186/s13099-025-00755-8

Cell migration switch increases it.

Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Sources: doi 10.1038/s41522-022-00352-6; PMC11897119. doi 10.1038/s41522-022-00352-6 · PMC11897119

Immune support reduces it.

10.1371/journal.ppat.1000703 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1371/journal.ppat.1000703

Immune balance reduces it.

PMC2822614 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “Overwhelming data in both humans and mice reveal a clear and surprisingly specific role for IL-17 in protection against the fungus Candida albicans, a commensal microbe of the human oral cavity, gastrointestinal tract, and reproductive mucosa”. doi 10.4049/jimmunol.1500909 · PMC2822614

Innate immune sensor reduces it.

10.1128/msphere.00467-24 — 11992285 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1128/msphere.00467-24

Calms body-wide inflammation increases it.

10.1016/j.mib.2011.07.015 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.1016/j.mib.2011.07.015

Fasting insulin increases it.

Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Sources: doi 10.1038/s41522-022-00352-6; PMC11897119. doi 10.1038/s41522-022-00352-6 · PMC11897119

Insulin sensitivity reduces it.

Verbatim: “Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia”. doi 10.3390/jcm8010076

Resists infection reduces it.

PMC10154278 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “The IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL-6, neutrophil-recruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgrowth”. doi 10.4049/jimmunol.1500909 · PMC10154278

Gum health reduces it.

10.3390/pathogens11030335 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.3390/pathogens11030335

Urinary health reduces it.

https://www.merckmanuals.com/professional/infectious-diseases/urinary-tract-infections/fungal-urinary-tract-infections — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Sources: doi 10.1038/s41522-022-00352-6; PMC11897119. doi 10.1038/s41522-022-00352-6 · PMC11897119

Estrogen balance increases it.

10.3389/fcimb.2023.1245808 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.3389/fcimb.2023.1245808

Micronutrient status reduces it.

10.3390/nu17111815 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. doi 10.3390/nu17111815

Lowers cortisol increases it.

Candidiasis is an opportunistic infection of immunocompromised hosts; immunosuppression is the dominant risk factor. PMC7392032

It reduces Nails.

10.1186/s13104-025-07197-0 — Drawn from reviews of neighboring outcomes rather than from studies of this outcome itself, which is weaker evidence, and the map marks it so. Verbatim: “Onychomycosis is a fungal infection of the nail apparatus caused by dermatophytes, Candida and non-dermatophytic molds”. doi 10.1186/s13104-025-07197-0 · PMID 27904057

It reduces Digestion.

10.3390/microorganisms14061365 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3390/microorganisms14061365

It reduces Urinary health.

10.1128/cmr.00076-09 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.1128/cmr.00076-09

It reduces Gum health.

10.3389/fmicb.2022.911623 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3389/fmicb.2022.911623

It reduces Skin.

https://www.merckmanuals.com/professional/dermatologic-disorders/fungal-skin-infections/candidiasis-mucocutaneous — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm.

It reduces Immune balance.

10.3390/jof8040386 — Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm. doi 10.3390/jof8040386

It increases Daily energy.

Supported by the reviews of this outcome as a whole. No separable effect size has been reported for this arm.

Helico (Gastric Colonization Defense) →