Punicalagin (from pomegranate extract)
Punica granatum
Pomegranate quiets the inflammation master switch in cultured cells, keeps the p53 alarm audible, and turns down the call for new blood vessels.
What the evidence shows
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Punicalagin is the heavy tannin pomegranate is famous for, and in the dish it does most of the work: inflammation switch down, blood-vessel signal down, the self-destruct program left free to run.
In mice whose blood fats were driven up, pomegranate's punicalagin improved liver fat handling, cut oxidative damage and restored mitochondrial function.
Blocks the bacterium's acid-survival enzyme and works in synergy with metronidazole; eight days cut gastritis in rats.
Pomegranate rind is dense with punicalagin; it triggers the cell's master switch for antioxidant genes, arming cells before oxidative damage lands.
Where it appears
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