Th17 immune arm

The immune cell type most consistently reduced when a treatment works in this illness.

Heart muscle inflammation increases it.

The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551

Immune signaling increases it.

The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551

Immune cell summons increases it.

The summons that calls t cells into the heart — and blocking it saved lives without touching the virus. An engineered decoy version 'had significantly reduced heart/body weight ratio and serum CK-MB level, increased survival rate and improved heart histopathology'. And the mechanism is explicit: 'this therapeutic effect was not attributable to an enhanced viral clearance, but to a blunted Th1 immune response' (pmc3062568 — Direct Gene Transfer with ip-10 Mutant Ameliorates Mouse cvb3-Induced Myocarditis by Blunting Th1 Immune Responses). ⇒ you can save the heart without killing more virus. the immune response, not the infection, is doing the damage at this stage. REFUTED ON A SECOND READING. This link was shown by linked steps until a source was opened that does not support it: “Compared with vector or no treatment, pIP-10-AT treatment had significantly reduced heart/body weight ratio and serum CK-MB level, increased survival rate and improved heart histopathology, suggesting an ameliorated myocarditis. This therapeutic effect was not attributable to an enhanced viral clearance, but to a blunted Th1 immune response, as evidenced by significantly decreased splenic CD4+/CD8+IFN-γ+ T cell percentages and reduced myocardial Th1 cytokine levels.” — Direct Gene Transfer with IP-10 Mutant Ameliorates Mouse CVB3-Induced Myocarditis by Blunting Th1 Immune Responses. [journal/year/volume/pages NOT READ]. doi 10.1371/journal.pone.0018186

It increases Inflammatory signaling.

The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551

It reduces Heart muscle cell.

The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551

Myocarditis Antidote (Cardiac Inflammation Resolution) →