Immune signaling
This signal helps decide which kind of immune cell the body makes. In this illness it pushes toward the type that attacks heart muscle, which is why it falls when treatments work.
In depth
A cytokine that drives immune cells toward the damaging phenotype.
What drives it
Heart muscle inflammation increases it.
The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551
What it drives
It increases Th17 immune arm.
The T cell that does the damage in this illness. Of all the immune cell types, this one keeps appearing when a treatment works: myricetin 'significantly decreased the percentage of Th17 cells in spleen and plasma IL-17A level' (doi 10.1016/j.ejphar.2023.175551 — Myricetin ameliorates experimental autoimmune myocarditis in mice by modulating immune response and inhibiting MCP-1 expression), and emodin works on the same axis in the viral model. IL-12 pushes cells down this road; IL-17 is what they release when they arrive. It is the most consistently targeted step in the whole disease. doi 10.1016/j.ejphar.2023.175551
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.