Preeclampsia risk
Gestational hypertension with organ involvement↓
Also searched as Gestational hypertension with organ involvement.
It is a vessel-lining disease before it is a blood-pressure reading, which is why endothelial function sits upstream of it.
In depth
A pregnancy disorder of new high blood pressure with organ involvement, rooted in the endothelium.
What it drives
It reduces Blood flow (nitric oxide).
This review documents that in preeclampsia placental and systemic oxidative stress uncouples and post-translationally impairs endothelial nitric oxide synthase, lowering eNOS-derived nitric oxide bioavailability and driving endothelial dysfunction. doi 10.1016/j.redox.2021.101861 · PMID 33548859
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.