Polyamines
Ornithine-derived polycations
Also searched as Ornithine-derived polycations.
Spermidine Induces Autophagy, which is one of the few dietary compounds with a direct line to a hallmark of aging. Human outcome data is far thinner than the mechanistic interest.
In depth
Spermidine, spermine and putrescine — polycations from ornithine, abundant in fermented foods.
What drives it
Gut barrier increases it.
Microbial polyamine production is a significant source. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
What it drives
It increases Cellular cleanup.
Spermidine induces autophagy - one of the few dietary compounds with a direct line to a hallmark of aging. Human outcome data is far thinner than the mechanistic interest. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
It reduces Cellular aging.
10.1186/s12964-024-01881-7 — Via the autophagy arm. Carried by the intermediary-metabolism and clinical reviews. doi 10.1186/s12964-024-01881-7 · PMC9967593
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.