Interferon response
Interferon-induced antiviral state
Also searched as Interferon-induced antiviral state.
It works by warning the neighbors: an infected cell secretes interferon and the cells around it switch on hundreds of antiviral genes before the virus reaches them. You want it responsive and then quiet again — held on, it becomes the disease.
In depth
The type-1 interferon program — the first-line antiviral response that puts cells into a defensive state.
What drives it
Pathogen tripwire increases it.
PAMPs are recognized by host pattern-recognition receptors, initiating the interferon system as a core innate defense against viral infection (PMC11172372). Provenance: the identifier previously cited here (PMC7255347) could not be confirmed to resolve and has been replaced with sources actually read. PMC11172372
What it drives
It increases Cytokine signaling.
Note: a JAK-STAT-independent route also exists -- IFN-beta can bind IFNAR1 without IFNAR2 and activate a distinct gene response. Provenance: previously cited PMC7255347 could not be confirmed and has been replaced. PMC7255347
It increases Immune support.
leprae infection persistent IFN exposure suppresses effective pathogen clearance. Acute IFN activates immunity; sustained IFN suppresses it. Provenance: previously cited PMC7255347 could not be confirmed and has been replaced. PMC7255347
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.