Gasotransmitter signaling
Hydrogen sulfide
Also searched as Hydrogen sulfide.
A relaxation route that runs in parallel to nitric oxide rather than through it — relevant where the NO pathway is impaired.
In depth
Hydrogen sulfide, alongside nitric oxide and carbon monoxide, relaxes vascular smooth muscle.
What drives it
Master antioxidant increases it.
H2S is generated from cysteine metabolism, sharing substrate with glutathione synthesis. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
Sulfur clearance route increases it.
Hydrogen sulfide is a by-product of the same transsulfuration enzymes. Carried by the intermediary-metabolism and clinical reviews. doi 10.1016/j.molmet.2023.101755 · PMC9967593
Blood flow (nitric oxide) increases it.
H2S and NO signaling are mutually reinforcing gasotransmitter arms — the forward edge's own quote asserts the reciprocity. doi 10.21037/tau-2025-419 · PMC11988752
What it drives
It increases Vessel wall muscle.
Hydrogen sulfide relaxes vascular smooth muscle in parallel to nitric oxide rather than through it. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
It increases Blood flow (nitric oxide).
H2S and NO signaling are mutually reinforcing gasotransmitter arms. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
It increases Sexual function.
A relaxation route that remains available where the nitric oxide pathway is impaired. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.