Fat assembly enzyme
Glycerol-3-phosphate acyltransferase (GPAT)
Also searched as Glycerol-3-phosphate acyltransferase (GPAT).
Rebuilding fat is a four-enzyme assembly line, and this is the first station. It takes the glucose-derived backbone and welds the first fatty acid onto it. Once that happens the molecule is committed to going back into storage. Blocking the last station stops the final bond; blocking this one would stop the whole return. Nothing in this formula reaches it, and that is worth saying plainly rather than leaving out.
In depth
The first enzyme of putting fat back — it takes the backbone and attaches the first fatty acid, committing the molecule to storage again.
What drives it
Glycerol backbone increases it.
The first step of putting fat back — named only in the arabic source. The full rebuilding sequence is set out there: 'مسار تخليق الدهون الجلسرين... الجلسرين-3-فوسفات أسيلترانسفيراز (GPAT)... حمض الليسوفوسفاتيديك أسيلترانسفيراز (LPAT)... فوسفاتيز حمض الفوسفاتيديك (PAP)... ديجليسريد أسيلترانسفيراز (DGAT)' = the glycerolipid synthesis pathway runs gpat → lpat → pap → dgat (chemistrysources.com / JoVE العربية — تحلل الدهن (arabic)). This matters because the MAP already had the last enzyme and not the first. This one takes the glycerol-3-phosphate backbone and puts the first fatty acid back onto it — it is the committed step, the point of no return for a fatty acid that was just released. A driver that inhibits the last enzyme stops the final bond. A driver that inhibited this one would stop the whole return. Nothing in this formula reaches it — stated as a limit, not hidden.
What it drives
It increases Fat re-storage.
The first step of putting fat back — named only in the arabic source. The full rebuilding sequence is set out there: 'مسار تخليق الدهون الجلسرين... الجلسرين-3-فوسفات أسيلترانسفيراز (GPAT)... حمض الليسوفوسفاتيديك أسيلترانسفيراز (LPAT)... فوسفاتيز حمض الفوسفاتيديك (PAP)... ديجليسريد أسيلترانسفيراز (DGAT)' = the glycerolipid synthesis pathway runs gpat → lpat → pap → dgat (chemistrysources.com / JoVE العربية — تحلل الدهن (arabic)). This matters because the MAP already had the last enzyme and not the first. This one takes the glycerol-3-phosphate backbone and puts the first fatty acid back onto it — it is the committed step, the point of no return for a fatty acid that was just released. A driver that inhibits the last enzyme stops the final bond. A driver that inhibited this one would stop the whole return. Nothing in this formula reaches it — stated as a limit, not hidden. Sources: PMC13031129. PMID 14641009 · PMC13031129
It increases Membrane lipid signaling.
GPAT initiates glycerophospholipid synthesis, supplying the phosphatidate from which membrane phospholipids are built. PMID 2106290
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.