Membrane lipid signaling
Protein kinase C (PKC) activation
Also searched as Protein kinase C (PKC) activation.
The kinase that irritant plant compounds cannot switch on is opened by two everyday phospholipids, both already used in supplements for unrelated reasons. what has been shown is that the lock accepts this key, and separately that turning this lock releases fat. Nobody has yet turned it this way and measured the fat. That is a real lead and it is not yet a real ingredient.
In depth
Two ordinary membrane fats — already common supplement ingredients — that bind and open the phorbol-proof kinase.
What drives it
Fat assembly enzyme increases it.
GPAT initiates glycerophospholipid synthesis, supplying the phosphatidate from which membrane phospholipids are built. PMID 2106290
What it drives
It increases The Phorbol-Proof Kinase.
The second key is an ordinary membrane fat. 'PKC-zeta selectively binds phosphatidic acid (PA) and phosphatidylserine (PS) and weakly to phosphatidylglycerol' (doi 10.3390/biomedicines9010045 — Identification of Key Phospholipids That Bind and Activate Atypical PKCs). ⇒ the kinase that irritant plant compounds cannot touch is opened by two phospholipids that are already everyday supplement ingredients — both are already carried elsewhere in this catalog for entirely different purposes. Stated at its exact strength and NO further: this is a binding-and-activation finding on the kinase. It is not a fat-release experiment. Nobody has shown that swallowing either phospholipid releases fat in a person. What is shown is that the lock accepts this key, and separately that turning this lock releases fat. Nobody has yet turned it this way and measured the result. doi 10.3390/biomedicines9010045
It increases The Two-Way Valve.
Phosphatidylcholine is the obligate phosphocholine donor that sphingomyelin synthase transfers onto ceramide. doi 10.1016/j.bbalip.2013.06.006 · PMC12132366
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.