Antiviral sensor relay
Mitochondrial antiviral signaling (MAVS)
Also searched as Mitochondrial antiviral signaling (MAVS).
Sitting on the mitochondria, this protein raises the antiviral response when it detects an invader. The virus destroys it early, which blinds the cell to what is happening inside it.
In depth
The mitochondrial signal that triggers the cell’s antiviral defense.
What drives it
Viral protease 3C reduces it.
It blinds the alarm before the alarm can ring. '3C protease cleaves mitochondrial antiviral-signaling protein (mavs) and trif, which are important for downstream antiviral responses such as the activation of NF-κB, 2′-5′ OAS, PKR, and Mx, and caspase-dependent apoptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). And 2A does the same from another angle: it 'disrupts NF-κB activation by cleaving NFAT5 and SQSTM1'. ⇒ the cell has a sensor that would raise the antiviral defense. the virus cuts the sensor first. PMID 37175422
What it drives
It reduces Coxsackievirus B3.
It blinds the alarm before the alarm can ring. '3C protease cleaves mitochondrial antiviral-signaling protein (mavs) and trif, which are important for downstream antiviral responses such as the activation of NF-κB, 2′-5′ OAS, PKR, and Mx, and caspase-dependent apoptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). And 2A does the same from another angle: it 'disrupts NF-κB activation by cleaving NFAT5 and SQSTM1'. ⇒ the cell has a sensor that would raise the antiviral defense. the virus cuts the sensor first. PMID 37175422
It reduces Viral replication.
MDA5-MAVS signaling is the innate sensor arm that restricts EMCV replication; loss of MAVS gives uncontrolled infection. PMID 16785313
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.