Adrenaline receptors
β1/β2-adrenoceptors
Also searched as β1/β2-adrenoceptors.
You want them responsive. These two receptors carry the bulk of adrenaline-driven fat release in human subcutaneous tissue. Each driver here carries its own study — open the receipt to see the depot, the design and the figure.
In depth
The two adrenaline receptors that carry the bulk of fat release in people — the third one usually advertised is present, but carries little of it.
What drives it
Alertness chemical increases it.
10.1038/s41467-023-37808-y — A correction, not an addition — and it overturns something this MAP had wrong. 'Dans l'adipocyte HUMAIN, les effets stimulants des catécholamines sur la lipolyze sont relayés par des RÉCEPTEURS β1- ET β2-ADRÉNERGIQUES. LE RÔLE DU RÉCEPTEUR β3-ADRÉNERGIQUE SEMBLE NÉGLIGEABLE dans LE TISSU ADIPEUX SOUS-CUTANÉ et reste discutable dans d'autres dépôts adipeux' = in the human fat cell the stimulating effects of epinephrine run through beta-1 and beta-2 receptors; the beta-3 receptor's role appears negligible in subcutaneous fat (Lafontan M., Obésité humaine et système nerveux sympathique, OCL 2003 (INSERM U586, Toulouse) — FRANÇAIS). The beta-3 receptor is the one most often named in animal work and in supplement marketing. In people, in the fat under the skin, it is not the one that matters. Any evidence resting on beta-3 in rodents says little about a human subcutaneous depot. doi 10.1038/s41467-023-37808-y
What it drives
It increases cAMP-making enzyme.
10.3389/fphar.2018.00904 — A correction, not an addition — and it overturns something this MAP had wrong. 'Dans l'adipocyte HUMAIN, les effets stimulants des catécholamines sur la lipolyze sont relayés par des RÉCEPTEURS β1- ET β2-ADRÉNERGIQUES. LE RÔLE DU RÉCEPTEUR β3-ADRÉNERGIQUE SEMBLE NÉGLIGEABLE dans LE TISSU ADIPEUX SOUS-CUTANÉ et reste discutable dans d'autres dépôts adipeux' = in the human fat cell the stimulating effects of epinephrine run through beta-1 and beta-2 receptors; the beta-3 receptor's role appears negligible in subcutaneous fat (Lafontan M., Obésité humaine et système nerveux sympathique, OCL 2003 (INSERM U586, Toulouse) — FRANÇAIS). The beta-3 receptor is the one most often named in animal work and in supplement marketing. In people, in the fat under the skin, it is not the one that matters. Any evidence resting on beta-3 in rodents says little about a human subcutaneous depot. doi 10.3389/fphar.2018.00904
It increases Releases stored fat.
PMC1909425 — A correction, not an addition — and it overturns something this MAP had wrong. 'Dans l'adipocyte HUMAIN, les effets stimulants des catécholamines sur la lipolyze sont relayés par des RÉCEPTEURS β1- ET β2-ADRÉNERGIQUES. LE RÔLE DU RÉCEPTEUR β3-ADRÉNERGIQUE SEMBLE NÉGLIGEABLE dans LE TISSU ADIPEUX SOUS-CUTANÉ et reste discutable dans d'autres dépôts adipeux' = in the human fat cell the stimulating effects of epinephrine run through beta-1 and beta-2 receptors; the beta-3 receptor's role appears negligible in subcutaneous fat (Lafontan M., Obésité humaine et système nerveux sympathique, OCL 2003 (INSERM U586, Toulouse) — FRANÇAIS). The beta-3 receptor is the one most often named in animal work and in supplement marketing. In people, in the fat under the skin, it is not the one that matters. Any evidence resting on beta-3 in rodents says little about a human subcutaneous depot. PMC1909425
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.