What is behind Heavy Metals & Toxins
Glutathione — the body's main built-in antioxidant, made inside cells throughout the body (liver, eyes, lungs, immune cells and more) to neutralize harmful oxidants and help clear toxins. Evidence A — Human trial evidence.
The transcription factor that commands the body's own antioxidant and detoxification arsenal. Evidence A — Human trial evidence.
How much lead, cadmium, mercury or arsenic is actually in the body, measured in blood, urine or tissue.
Metal excretion — metal actually leaving the body in urine or stool, not merely moved from one tissue to another.
Metallothionein — a small cysteine-rich protein the body makes to grab heavy metals and hold them where they cannot react.
Evidence on these pathways
Nrf2 → Detoxification & Clearance. “NRF2-induced expression of ARE-containing cytoprotective genes in response to cell stress forms a network of cooperating enzymes involved in phase I, II, and III drug detoxification reaction and elimination of pro-oxidants to maintain cellular homeostasis.” — NRF2, a Transcription Factor for Stress Response and Beyond. International Journal of Molecular Sciences, 2020, vol 21(13), 4777. doi:10.3390/ijms21134777
Nrf2 → Atopic Dermatitis. “In addition, we found that the production of Th2 cytokines is negatively regulated by NRF2, and the induction of NRF2 by cardamonin contributed to suppressing oxazolone-induced Th2 cytokine production and oxidative damages in vivo.” — Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production. Antioxidants 2020;9(9):834. doi:10.3390/antiox9090834
Formulas that act on these pathways
Acts on 4 of these pathways: Glutathione, Nrf2, Metal Excretion, Metallothionein.
Acts on 3 of these pathways: Glutathione, Nrf2, Metallothionein.
Acts on 3 of these pathways: Glutathione, Nrf2, Metallothionein.
Acts on 2 of these pathways: Nrf2, Metallothionein.
What this page does not claim
This page names the pathways involved and the published evidence on each. It does not claim that any formula treats, cures or prevents Heavy Metals & Toxins. A pathway opens here only on graded, published evidence, under a standard fixed before the evidence was gathered, and every figure above carries its grade.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.